It’s your single place to instantly Example. over 18 million articles from more than What is known about tumour proliferation rates to choose between accelerated fraction or hyperfraction? Komaki R, Seiferheld W, Curran W, et al. The CALGB group compared induction chemotherapy with two carboplatin and taxol cycles, followed by concomitant chemo-radiotherapy, vs concomitant chemo-radiotherapy alone . Patients treated with sequential CT/RT had a better outcome than those treated with concomitant treatment (3-year DFS rate 27% vs. 13%; p = 0.04). No significant dose-response relationship was found in terms of LRC. tumeur classbe T3b-4 ou de 65 & 80 % en cas de T2-3a Therapeutic strategies for muscle invasive bladder cancer are et le contrble locorkgional est excellent : proche de currently evolving. Concurrent chemoradiotherapy (C-CRT) with cisplatin based chemotherapy is the current standard of treatment (4-6). discover and read the research If a drug abuser ingests or misuses two or more drugs, either at the same time or almost at the same time, this is also called "concomitant drugs". Overall survival at 2 years, 3 years, and 5 years were 58.7%, 52.8%, and 42.4%, respectively. Google Scholar This study was carried out to assess the outcome of concomitant chemotherapy with a “concomitant boost” radiotherapy in the treatment of advanced unresectable head and neck cancer patients. Background We compared concomitant cisplatin and irradiation with radiotherapy alone as adjuvant treatment for stage III or IV head and neck cancer. Concurrent chemotherapy and radiation provide for the systemic treatment of patients with micrometastatic and macrometastatic disease and simultaneously enhance local therapy in the form of chemosensitized external beam radiotherapy (EBRT). 26,34–36 Identification of new cytotoxic or targeted agents that can be combined concomitantly to radiotherapy … Background: Chemoradiotherapy (CRT) including three cycles of cisplatin is considered the standard of care for locally advanced head and neck squamous cell carcinoma (LA-HNSCC). Concurrent chemotherapy in 1980s Studies Stages Arms Results Hreschyshyn et al (1979)1 GOG 04 IIIB-IVA RT alone vs RT + HU Superiority in DFS and OS rates in RT+ HU arm. Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more. Address reprint requests to Bin S. Teh, MD, Baylor College of Medicine, One Baylor Plaza, 165B Houston, TX 77030. Do not surround your terms in double-quotes ("") in this field. We are evaluating the feasibility of the concomitant use of chemotherapy retrospectively. shielding and concomitant high-dose rate intracavitary brachytherapy with 192-iridium remote after loading system for 6 Gy to point A of the Manchester method). The CALGB group compared induction chemotherapy with two carboplatin and taxol cycles, followed by concomitant chemo-radiotherapy, vs concomitant chemo-radiotherapy alone . Copyright © 2000 W.B. Stehman et al (1988)3 GOG 56 … Concomitant radiotherapy and chemotherapy for early-stage nasopharyngeal carcinoma. Concurrent chemotherapy for locally advanced head and neck cancer results in an absolute survival benefit of 6.5% at 5 years when compared with radiation alone. The main acute toxicities were hematologic toxicity, esophagitis, and alopecia. Seven hundred sixteen patients were included in this trial. A total of 70 Gy was delivered over 6 weeks. In … e12040 Background: Chemotherapy followed by endocrine therapy is the standard adjuvant treatment strategy for estrogen receptor-positive breast cancer patients. Patients who received concurrent chemotherapy were of younger age (mean age 60.5 years vs 62.9 years; P < 0.001), ... As in many clinical situations, the absolute benefit of concomitant chemotherapy will be driven in large part by the absolute risk of recurrence and death in the patient population being treated. Whether concomitant drug abuse leads to an increased number of deaths was … Hematologic toxicities and alopecia were the major acute toxicities during induction chemotherapy; 8.7% of the patients experienced grade 3–4 neutropenia and alopecia. Start a 14-Day Trial for You and Your Team. The patients were randomly assigned (by draw of lots) either of two groups; group I, the 0600 hour cisplatin administration and group II, the 1800 hour cisplatin administration group. Date of Web Publication: 15-Feb-2016: Correspondence Address: Sushil Dashrath Meshram … 15,000 peer-reviewed journals. Significant toxicity (47%) in HU arm. Include any more information that will help us locate the issue and fix it faster for you. After a median follow-up of 6.7 (4.3–9) years, we decided to prospectively evaluate the late effects of these two strategies. Concurrent chemo-radiotherapy is a valuable method for adjuvant treatment of breast cancer which is under ongoing research program in our hospital. Conventional vs concomitant boost radiotherapy with concurrent cisplatin in advanced head and neck cancer Sushil Dashrath Meshram, Krishna M Kamble, Ashok K Diwan, Vijay K Mohobia Department of Radiation Therapy and Oncology, Government Medical College and Hospital, Nagpur, Maharashtra, India . These include induction chemotherapy, concomitant chemoradiotherapy, ... (CALGB) study 9431 combined induction chemotherapy and concurrent chemoradiotherapy, in the hope that patients with NSCLC may be better served by receiving both approaches to treatment rather than … Neither PFS, cancer-free survival nor OS was statistically significantly improved in the chemotherapy arm at the time of reporting (median follow-up not stated), although there is a trend in favour of the chemotherapy [five year PFS 61% with RT vs. 74% with CT-RT: p = 0.10, five year OS 73% with RT versus 78% with CT-RT, p = 0.41]. To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one. PURPOSE: Early-stage nasopharyngeal carcinoma (NPC) continues to carry a failure rate of 15% to 30% when treated with radiotherapy alone; the benefit of concomitant radiotherapy and chemotherapy (CCRT) in early-stage NPC is unclear. The addition of concurrent chemotherapy to RT in patients with high-risk major SGCs did not offer an advantage in OS. 26,34–36 Identification of new cytotoxic or targeted agents that can be combined concomitantly to radiotherapy … Conclusion:This combined chemoradiotherapy approach is safe and efficacious for advanced unresectable head and neck cancer. Introduction Carcinomas of the major salivary glands constitute a heterogeneous group of rare malignant neoplasms, accounting for less than 5% of newly diagnosed head and neck cancers. Reset filters. Carboplatin plus 5-fluorouracil (carbo-5FU) is another accepted treatment option with a different toxicity profile. §Otorhinolaryngology, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX. Saunders Company). Submitting a report will send us an email through our customer support system. 7–10 Although the response rate to induction chemotherapy is approximately 30 to 40%, long-term survival remains unchanged. We therefore performed a retrospective ana-lysis in a mono-institutional group with newly diagnosed Historic cancer treatment protocols often required patients to undergo chemotherapy and radiation separately. Background: Chemoradiotherapy (CRT) including three cycles of cisplatin is considered the standard of care for locally advanced head and neck squamous cell carcinoma (LA-HNSCC). every week. Carboplatin (area under the curve of 6) was given as a 30-min infusion on d 1 and 28. (9) Concurrent with this change in the level of enforcement of RBT was an extensive publicity campaign, which warned drinking drivers of their increased risk of detection by RBT units. – Springer Journals. Select data courtesy of the U.S. National Library of Medicine. : Sequential vs. concurrent chemotherapy and radiation therapy for inoperable non-small cell lung cancer (NSCLC): analysis of failures in a phase III study (RTOG 9410). Find any of these words, separated by spaces, Exclude each of these words, separated by spaces, Search for these terms only in the title of an article, Most effective as: LastName, First Name or Lastname, FN, Search for articles published in journals where these words are in the journal name, /lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l, Radiation therapy in the management of patients with unresectable stage III A patients and III B non-small cell lung cancer, Radiation and chemotherapy for patients with stage III non-small cell lung cancer, Continuous, hyperfactionated, accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small cell lung cancer: mature data from the randomised multicentre trial. Concomitant chemotherapy was Des chimiothkapies ayant donni destaux de rkponse composed of cisplatin (20 mg/m2) and 5-fluorouracil tlevCs et le cisplatine ktant d&it comme un radiopo- (500 mg/m2) that were administered each Monday and tentialisateur, nousavons rka1i.k une ttude de phaseII Thursday during radiotherapy. Purpose: In 1996, a multicenter randomized study was initiated that compared sequential vs. concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) after breast-conserving surgery (ARCOSEIN study). We use cookies to help provide and enhance our service and tailor content and ads. Conventional vs concomitant boost radiotherapy with concurrent cisplatin in advanced head and neck cancer October 2015 Journal of Cancer Research and Therapeutics 11(4):770 1 Primary sites include the parotid, submandibular, and sublingual glands. The NSCLC Collaborative Group performed a meta-analysis of randomized trials directly comparing concomitant versus sequential radiochemotherapy. Cisplatinum (100 mg/m2) was given intravenously during week 1 and week 5. vs concurrent chemoradiotherapy with TPF in patients with locally . 2005; 23 (16s):7014. Our experience suggests that concurrent chemotherapy and concomitant boost radiotherapy approaches appear promising. Concurrent chemotherapy is medication provided alongside radiation therapy for cancer patients. Phase III study of concurrent chemotherapy and radiotherapy (CT/RT) vs CT/RT followed by surgical resection for stage IIIA (pN2) non-small cell lung cancer (NSCLC): outcomes update of North American Intergroup 0139 (RTOG 9309) (Abstract) Proc Am Soc Clin Oncol. Published. Aprks cystectomie, le taux de survie g Concurrent chemotherapy and radiotherapy for bladder 5 ans varie de 15 ZI 30 % pour les patients atteints de cancer: an overview. The concurrent chemotherapy consisted Conclusions: Long-term results of this schedule are encouraging However. The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. After a median follow-up of 6.7 years (range, 4.3-9 years), we decided to prospectively evaluate the late effects of these 2 strategies. Saunders Company. Chemotherapy: All the patients were to receive concomitant cisplatin in dose of 30 mg/m 2 i.v. Concurrent chemo-radiotherapy is a valuable method for adjuvant treatment of breast cancer which is under ongoing research program in our hospital. Phase II trial, Chemo-radiotherapy for stage III unresectable non-small cell lung cancer—long-term results of a prospective study, Induction chemoterapy for non small cell carcinoma of the lung: limitations and lessons. Look in other contemporaneous works to see whether that idea was common then. [Abstract] Int J Radiat Oncol Biol Phys 48 (3 suppl): A-5, 113, 2000. Finally, accelerated radiotherapy has been shown to lead to improved locoregional control and survival in one randomized study. Unlimited access to over18 million full-text articles. ... 30 Baas P, Belderbos JSA, Senan S, et al. Randomized. They were placed on your computer when you launched this website. Radiation Therapy Oncology Group, Eastern Cooperative Oncology Group, and Southwest Oncology Group, Hyperfractionated radiation therapy with or without concurrent low-dose daily carboplatin/etoposide for stage III non-small-cell lung cancer: a randomized study, Jeremic, B; Shibamoto, Y; Acimovic, L; Milisavljevic, S, Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small cell lung cancer, Long term benefit is observed in a phase III comparison of sequential vs. concurrent chemo-radiation for patients with unresected stage III NSCLC: RTOG 9410, Sequential versus concurrent chemo-radiation (RT-CT) in locally advanced non small cell lung cancer (NSCLC): a French randomized phase III trial of GLOT-GFPC (NPC 95-01 study), Concurrent versus sequential chemoradiotherapy with cisplatin and vinorelbine in locally advanced non-small cell lung cancer: a randomized study, Optimizing chemoradiation therapy approaches to unresectable stage III non-small cell lung cancer, Programming of radiotherapy in the treatment of non-small cell lung cancer-a way to advance care, Inoperable non-small cell lung cancer: radiation with or without chemotherapy, Thoracic radiation therapy alone compared with combined chemoradiotherapy for locally unresectable non- small-cell lung cancer. Patients with newly diagnosed inoperable non-small cell lung cancer received paclitaxel (100 mg/m2) as a 1-h infusion on d 1,8,15,28,35, and 42. A “concomitant boost” external beam radiotherapy approach was used with twice-daily treatment delivered during the last 2 weeks. advanced squamous cell carcinoma of the head and neck. 64 - Segawa Y, Kiura K, Takigawa N, et al. 7 Integration of a third chemotherapy agent to the induction and concurrent chemoradiotherapy regimen may improve distant and local disease control, respectively. The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. 16. Table 1. The optimal integration of chemotherapy with radiotherapy (either conventional or altered fractionation) in the management of advanced unresectable head and neck cancers is still unclear. Purpose: The previous individual patient data meta-analyses of chemotherapy in locally advanced non-small-cell lung cancer (NSCLC) showed that adding sequential or concomitant chemotherapy to radiotherapy improved survival. Carboplatin plus 5-fluorouracil (carbo-5FU) is another accepted treatment option with a different toxicity profile. Copy and paste the desired citation format or use the link below to download a file formatted for EndNote. After a median follow-up of 6.7 years (range, 4.3-9 years), we decided to prospectively evaluate the late effects of these 2 strategies. This is a randomized, multicenter, phase III trial comparing induction chemotherapy with Docetaxel, Cisplatin and 5-Fluorouracil (TPF) followed by concurrent chemoradiotherapy (Arm A) to concurrent chemoradiotherapy alone (Arm B), in nasopharyngeal cancers staged as T2b, T3, T4 and/or with lymph node involvement (≥ N1. Bourhis J, Sire C, Graff P, et al. (10) In the present work, we measured the inactivation of methionine synthase and the concurrent homocysteine export rate of two murine and four human cell lines during nitrous oxide exposure. Concomitant versus sequential radiochemotherapy and print from thousands of the patients experienced grade 3–4 and. Misonidazole median survival in control arm 1.9 yrs sequential use of chemotherapy concomitant. About tumour proliferation rates to choose between accelerated fraction or hyperfraction significant toxicity 47! 52.8 %, long-term survival benefit compared with the sequential group for EndNote Oxford Press. - Segawa Y, Kiura K, Takigawa N, et al toxicity concurrent! Last 2 weeks the last 2 weeks C-CRT ) with cisplatin based chemotherapy is approximately 30 40. Radiation therapy for cancer patients the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and.... 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